Sleeping well and exercising not only improve your physical condition but also reduce the risk of heart disease caused by genetic mutations in immune cells. These mutations, common in people over 70, increase inflammation and the risk of heart attacks. Science confirms that good rest and moderate activity can counteract these hereditary effects.
The biology behind inflammation and cellular repair 🧬
Mutations in hematopoietic stem cells generate clones that promote chronic inflammation, accelerating atherosclerosis. Exercise regulates the expression of inflammatory genes, and deep sleep activates the lymphatic glia, eliminating metabolic waste. Both habits reduce NF-kB signaling, a key protein in the inflammatory response. In mice, physical activity decreased the expansion of these mutant clones by 30%.
The perfect heart attack: well-rested and in good shape 😅
The good news is that, if your genetics decided a heart attack is inevitable, at least you can choose to have it happen while well-rested and with your cardio up to date. Nothing like suffering a cardiac arrest while showing off good VO2 max levels. Studies suggest that with restorative sleep and exercise, the attack will be more bearable. Or, at the very least, you'll arrive at the hospital looking better.