Roasted Coffee Molecules Modulate Carbohydrate Digestion

Published on January 11, 2026 | Translated from Spanish
Image of dark roasted coffee beans and a steaming cup, with a superimposed molecular graphic representing interaction with digestive enzymes.

Molecules in Roasted Coffee Modulate Carbohydrate Digestion

Science discovers a new effect of coffee beyond caffeine. A recent study reveals that certain bioactive compounds generated when roasting the beans can alter the way our body processes carbohydrates. These findings open a fascinating perspective on how common dietary components influence key metabolic processes ☕.

The Mechanism Behind Digestive Modulation

The research focuses on molecules derived from coffee's chlorogenic acids. Their main action is to inhibit the alpha-glucosidase enzyme. This enzyme is crucial in the small intestine, as it breaks down complex carbohydrates into simple sugars for absorption. By interfering with this enzyme, the process slows down, reducing the speed at which glucose enters the bloodstream.

Key Points of the Discovered Effect:
  • The effect is similar, although less potent, to the mechanism of some medications for managing type 2 diabetes.
  • The concentration of these active molecules varies according to the roast degree, being higher in darker roasted coffees.
  • The coffee bean variety also determines the presence and amount of these compounds.
Science suggests that coffee not only wakes you up, but it might also be negotiating with sugars to take their time.

Research Context and Implications

It is important to note that these results come from in vitro experiments conducted in the laboratory. Therefore, more studies are still needed to confirm that this effect occurs in the same way in the human body. Nevertheless, the discovery is significant because it points to a research avenue on how diet can naturally modulate metabolism.

Factors Determining the Activity of the Compounds:
  • Roast Type: Dark roasts show greater inhibitory activity.
  • Bean Origin: The botanical variety and geographic origin influence it.
  • Preparation Method: Although the study focuses on the compounds in the roasted bean, the way the beverage is prepared could affect their extraction.

A Possible Explanation for a Common Sensation

This finding could provide a scientific basis for an experience many have had: after drinking a strong coffee accompanied by a sweet food, sometimes a more sustained energy is perceived, instead of a sugar spike followed by a sharp drop. The inter

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